Piroxicam Bate Cyclodextrin CAS No 96684-39-8 Pharmaceutical Formulation

Piroxicam β-Cyclodextrin Is An Effective Drug Carrier System

1.Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat arthritis, pain, and inflammation. It reduces inflammation and pain by inhibiting the cyclooxygenase (COX) enzyme in the body.

2.β-cyclodextrin is a cyclic sugar molecule that can form inclusion bodies to improve the solubility and stability of drugs. Beta cyclodextrin has a hollow structure that can "wrap" other molecules, thereby increasing its bioavailability and solubility.

Piroxicam β-cyclodextrin is a pharmaceutical formulation formed by combining piroxicam and β-cyclodextrin. Through the inclusion effect of β-cyclodextrin, the solubility and stability of piroxicam are significantly improved, thereby improving the bioavailability and release characteristics of the drug. Such formulations can be used to increase a drug's efficacy, reduce side effects, and improve the overall performance of the drug.

Product Paramete

Main Applications:

• Enhanced drug solubility: Piroxicam has low solubility in water, resulting in limited bioavailability. By combining piroxicam with beta-cyclodextrin, its solubility in water can be significantly increased, thereby improving the bioavailability and efficacy of the drug. This is particularly important for oral formulations, as oral drugs need to dissolve in the gastrointestinal tract in order to be absorbed.
• Improve drug stability: β-cyclodextrin can protect drugs from environmental factors (such as light, oxygen, moisture) and reduce the degradation rate of drugs. This makes drugs containing beta-cyclodextrin more stable during storage and use.
• Improve the controlled release performance of drugs: Piroxicam β-cyclodextrin complex can be used to prepare sustained-release or controlled-release dosage forms, which can extend the release time of the drug in the body, reduce the frequency of medication, and increase patient compliance.
• Reduce side effects: By improving the solubility and bioavailability of the drug, piroxicam beta-cyclodextrin complex can help reduce local irritation and gastrointestinal side effects of the drug. The inclusion effect of β-cyclodextrin helps reduce the direct contact between the drug and the gastrointestinal mucosa, thereby reducing irritation to the gastrointestinal tract.
• Preparation of special dosage forms: Piroxicam β-cyclodextrin can also be used to prepare injections, transdermal patches or other special dosage forms. These dosage forms can be used to meet different patient treatment needs and drug delivery routes.